Effect of Oriental Plant Drugs on Platelet Aggregation; III1. Effect of Chines Drug “Xiebai” on Human Platelet Aggregation

T. Okuyama; S. Shibata; M. Hoson; T. Kawada; H. Osada; T. Noguchi

doi:10.1055/s-2007-969113

Planta Medica, Table of Contents

Planta Med 1986; 52(3): 171-175
DOI: 10.1055/s-2007-969113

Full Papers

Effect of Oriental Plant Drugs on Platelet Aggregation; III¹. Effect of Chines Drug “Xiebai” on Human Platelet Aggregation

T. Okuyama² , S. Shibata² , M. Hoson³ , T. Kawada³ , H. Osada³ , T. Noguchi³

²Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Nozawa 1-35-23, Setagaya-ku, Tokyo, Japan.
³The Third Department of Surgery, St. Marianna University School of Medicine, Sugao 2095, Miyamae-ku, Kawasaki-shi, Japan.

1 Part II of this series: Okuyma, T., Kawasaki, C., Shibata, S., Hoson, M., Kawada, T., Osada, H., Noguchi, T. (1986) Planta Med. 132.

Abstract

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Abstract

The effect of the Chinese crude drug “Xiebai” and its components on human platelet aggregation induced by 2 µM ADP was studied. From the ethyl acetate-soluble fraction giving a remarkable inhibitory effect against platelet aggregation, N-p-coumaroyltyramine (1) and N-trans-feruloyl tyramine (2) were isolated as the active principles. Compound 2 showed a strong inhibitory activity against both the primary and secondary wave aggregation induced by 2 µM ADP of human platelet, whereas 1 was effective only against the primary aggregation. In comparison with the above compounds cinnamic acid derivatives (3-6) and tyramine (7) were also examined with respect to human platelet aggregation. Compounds 3 and 5 showed the inhibitory activity against both the primary and secondary wave aggregation as did as 2, while 6 inhibited only the primary aggregation, and 4 gave a lower effect. Compound 7 showed inhibition only upon the secondary aggregation.

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